{"id":1361,"date":"2020-09-23T16:49:25","date_gmt":"2020-09-23T14:49:25","guid":{"rendered":"https:\/\/2020.corlife.eu\/?page_id=1361"},"modified":"2025-01-20T17:44:24","modified_gmt":"2025-01-20T16:44:24","slug":"xellfree","status":"publish","type":"page","link":"https:\/\/corlife.eu\/en\/professionals\/xellfree\/","title":{"rendered":"Xellfree\u00ae"},"content":{"rendered":"<p><div class=\"fusion-fullwidth fullwidth-box fusion-builder-row-1 nonhundred-percent-fullwidth non-hundred-percent-height-scrolling fusion-equal-height-columns\" style=\"background-color: #ffffff;background-position: center center;background-repeat: no-repeat;padding-top:0px;padding-right:0px;padding-bottom:0px;padding-left:0px;margin-bottom: 0px;margin-top: -60px;border-width: 0px 0px 0px 0px;border-color:#e2e2e2;border-style:solid;\" ><div class=\"fusion-builder-row fusion-row\"><div class=\"fusion-layout-column fusion_builder_column fusion-builder-column-0 fusion_builder_column_1_1 1_1 fusion-one-full fusion-column-first fusion-column-last\" style=\"margin-top:0px;margin-bottom:0px;\"><div class=\"fusion-column-wrapper fusion-flex-column-wrapper-legacy\" style=\"background-position:left top;background-repeat:no-repeat;-webkit-background-size:cover;-moz-background-size:cover;-o-background-size:cover;background-size:cover;padding: 0px 0px 0px 0px;\"><style type=\"text\/css\">.fusion-breadcrumbs.fusion-breadcrumbs-1{font-size:18px;}.fusion-breadcrumbs.fusion-breadcrumbs-1 span a:hover{color:#003366 !important;}.fusion-breadcrumbs.fusion-breadcrumbs-1{color:rgba(0,51,102,0.32);}.fusion-breadcrumbs.fusion-breadcrumbs-1 a{color:rgba(0,51,102,0.32);}<\/style><div class=\"fusion-breadcrumbs fusion-breadcrumbs-1\"><span><span><a href=\"https:\/\/corlife.eu\/\">Home<\/a><\/span><\/span><\/div><style type='text\/css'>.reading-box-container-1 .element-bottomshadow:before,.reading-box-container-1 .element-bottomshadow:after{opacity:0.70;}<\/style><div class=\"fusion-reading-box-container reading-box-container-1\" style=\"margin-top:0px;margin-bottom:20px;\"><div class=\"reading-box reading-box-center\" style=\"background-color:rgba(255,255,255,0);border-width:0px;border-color:rgba(226,226,226,0);border-style:solid;\"><h2><font color=#003366><b>Xellfree<sup>\u00ae<\/sup><\/b><\/font><\/h2><\/div><\/div><div class=\"fusion-clearfix\"><\/div><\/div><\/div><\/div><\/div><div class=\"fusion-fullwidth fullwidth-box fusion-builder-row-2 myaccx hundred-percent-fullwidth non-hundred-percent-height-scrolling\" style=\"background-color: rgba(255,255,255,0);background-position: center center;background-repeat: no-repeat;padding-top:0px;padding-right:0px;padding-bottom:10px;padding-left:0px;margin-bottom: 0px;margin-top: -10px;border-width: 0px 0px 0px 0px;border-color:#e2e2e2;border-style:solid;\" ><div class=\"fusion-builder-row fusion-row\"><div class=\"fusion-layout-column fusion_builder_column fusion-builder-column-1 fusion_builder_column_1_1 1_1 fusion-one-full fusion-column-first fusion-column-last\" style=\"margin-top:0px;margin-bottom:20px;\"><div class=\"fusion-column-wrapper fusion-flex-column-wrapper-legacy\" style=\"background-position:left top;background-repeat:no-repeat;-webkit-background-size:cover;-moz-background-size:cover;-o-background-size:cover;background-size:cover;padding: 0px 0px 0px 0px;\"><div class=\"akkordeon\">\n\n\t\t<div class=\"akkordeon_maw_item akkordeon_maw_closed\" id=\"cellfreeallografts\" onclick=\"togglestate(this)\">\n\t\t\t<div class=\"title\">\n<h5>Zellfreie Allografts<\/h5>\n\t\t\t<\/div><br>\n\t\t\t<div class=\"content\">\n<!-- Nest -->\n\n\n<div class=\"fusion-builder-row fusion-builder-row-inner fusion-row\">\n<div class=\"fusion-layout-column fusion_builder_column_inner fusion-builder-nested-column-0 fusion_builder_column_inner_1_1 1_1 fusion-one-full fusion-column-first fusion-column-last\" style=\"width:100%;margin-top:0px;margin-bottom:20px;\"><div class=\"fusion-column-wrapper fusion-flex-column-wrapper-legacy\" style=\"background-position:left top;background-repeat:no-repeat;-webkit-background-size:cover;-moz-background-size:cover;-o-background-size:cover;background-size:cover;background-color:rgba(0,0,0,0);padding: 0px 0px 0px 0px;\"><div class=\"fusion-text fusion-text-1\"><p>Allografts, wie z.B. menschliche Herzklappen, sind anatomisch perfekt an ihre Aufgabe angepasst. Daher zeigen Allografts, fr\u00fcher auch als \"Homografts\" bekannt, grunds\u00e4tzlich gute Langzeitergebnisse. Der Nachteil von konventionellen Allografts ist, dass sie vom Immunsystem erkannt werden k\u00f6nnen. Dies kann zu einem Funktionsverlust des Allografts f\u00fchren und eine Reintervention oder Reoperation erfordern.<\/p>\n<\/div>\n<div class=\"fusion-clearfix\"><\/div><\/div><\/div>\n<\/div>\n\n\n<div class=\"fusion-builder-row fusion-builder-row-inner fusion-row\">\n<div class=\"fusion-layout-column fusion_builder_column_inner fusion-builder-nested-column-1 fusion_builder_column_inner_1_1 1_1 fusion-one-full fusion-column-first fusion-column-last\" style=\"width:100%;margin-top:0px;margin-bottom:20px;\"><div class=\"fusion-column-wrapper fusion-flex-column-wrapper-legacy\" style=\"background-position:left top;background-repeat:no-repeat;-webkit-background-size:cover;-moz-background-size:cover;-o-background-size:cover;background-size:cover;background-color:rgba(0,0,0,0);padding: 0px 0px 0px 0px;\"><div class=\"imageframe-align-center\"><span class=\" fusion-imageframe imageframe-none imageframe-1 hover-type-none\"><img decoding=\"async\" width=\"780\" height=\"230\" title=\"zellfreieallotransplantate\" src=\"https:\/\/corlife.eu\/wp-content\/uploads\/2020\/09\/zellfreieallotransplantate.png\" data-orig-src=\"\/wp-content\/uploads\/2020\/09\/zellfreieallotransplantate.png\n\" alt class=\"lazyload img-responsive wp-image-1274\" srcset=\"data:image\/svg+xml,%3Csvg%20xmlns%3D%27http%3A%2F%2Fwww.w3.org%2F2000%2Fsvg%27%20width%3D%27780%27%20height%3D%27230%27%20viewBox%3D%270%200%20780%20230%27%3E%3Crect%20width%3D%27780%27%20height%3D%27230%27%20fill-opacity%3D%220%22%2F%3E%3C%2Fsvg%3E\" data-srcset=\"https:\/\/corlife.eu\/wp-content\/uploads\/2020\/09\/zellfreieallotransplantate-200x59.png 200w, https:\/\/corlife.eu\/wp-content\/uploads\/2020\/09\/zellfreieallotransplantate-400x118.png 400w, https:\/\/corlife.eu\/wp-content\/uploads\/2020\/09\/zellfreieallotransplantate-600x177.png 600w, https:\/\/corlife.eu\/wp-content\/uploads\/2020\/09\/zellfreieallotransplantate.png 780w\" data-sizes=\"auto\" data-orig-sizes=\"(max-width: 700px) 100vw, 780px\" \/><\/span><\/div>\n<div class=\"fusion-clearfix\"><\/div><\/div><\/div>\n<\/div>\n\n<div class=\"fusion-builder-row fusion-builder-row-inner fusion-row\">\n<div class=\"fusion-layout-column fusion_builder_column_inner fusion-builder-nested-column-2 fusion_builder_column_inner_1_1 1_1 fusion-one-full fusion-column-first fusion-column-last\" style=\"width:100%;margin-top:0px;margin-bottom:20px;\"><div class=\"fusion-column-wrapper fusion-flex-column-wrapper-legacy\" style=\"background-position:left top;background-repeat:no-repeat;-webkit-background-size:cover;-moz-background-size:cover;-o-background-size:cover;background-size:cover;background-color:rgba(0,0,0,0);padding: 0px 0px 0px 0px;\"><div class=\"fusion-text fusion-text-2\"><p>Bei der \"Dezellularisierung\" werden die Zellen aus der Gewebespende entfernt. Es bleibt nur das zellfreie Bindegewebe \u00fcbrig. Das nun zellfreie Allograft beh\u00e4lt seine urspr\u00fcngliche Form und volle Funktionsf\u00e4higkeit. W\u00e4hrend Zellmarker die Individualit\u00e4t jedes einzelnen Menschen bestimmen, ist das Bindegewebe nicht immunologisch individualisiert. Zellfreie Allografts werden daher seltener als konventionelle (kryokonservierte) Allografts vom Empf\u00e4nger abgesto\u00dfen.<\/p>\n<\/div>\n<div class=\"fusion-clearfix\"><\/div><\/div><\/div>\n<\/div>\n\n\t\t\t<\/div>\n\t\t<\/div>\n\n\n<div class=\"akkordeon_maw_item akkordeon_maw_closed\" id=\"xellfree\" onclick=\"togglestate(this)\">\n\t\t\t<div class=\"title\">\n<h5>Xellfree<sup>\u00ae<\/sup>-Verfahren<\/h5>\n\t\t\t<\/div><br>\n\t\t\t<div class=\"content\">\n<!-- Nest -->\n\n\n<div class=\"carousel\">\n<p><i><small>Diese Slideshow gibt einen \u00dcberblick \u00fcber das Xellfree<sup>\u00ae<\/sup>-Verfahren.<\/small><\/i><\/p>\n<div class=\"slider\">\n\n <div class=\"smallslides\" id=\"smallslider\">\n    <div id=\"slide-1\" class=\"smallslidesItem\">\n<div class=\"fusion-builder-row fusion-builder-row-inner fusion-row\">\n<div class=\"fusion-layout-column fusion_builder_column_inner fusion-builder-nested-column-3 fusion_builder_column_inner_1_2 1_2 fusion-one-half fusion-column-first\" style=\"width:48%; margin-right: 4%;margin-top:35px;margin-bottom:20px;\"><div class=\"fusion-column-wrapper fusion-flex-column-wrapper-legacy\" style=\"background-position:left top;background-repeat:no-repeat;-webkit-background-size:cover;-moz-background-size:cover;-o-background-size:cover;background-size:cover;padding: 0px 0px 0px 0px;\">\n<span class=\" fusion-imageframe imageframe-none imageframe-2 hover-type-none\"><img decoding=\"async\" width=\"2560\" height=\"1564\" title=\"SlideshowProfessionals Xellfree1\" src=\"https:\/\/corlife.eu\/wp-content\/uploads\/2020\/09\/SlideshowProfessionals-Xellfree1-scaled.jpg\" data-orig-src=\"\/wp-content\/uploads\/2020\/09\/SlideshowProfessionals-Xellfree1-scaled.jpg\n\" alt class=\"lazyload img-responsive wp-image-1536\" srcset=\"data:image\/svg+xml,%3Csvg%20xmlns%3D%27http%3A%2F%2Fwww.w3.org%2F2000%2Fsvg%27%20width%3D%272560%27%20height%3D%271564%27%20viewBox%3D%270%200%202560%201564%27%3E%3Crect%20width%3D%272560%27%20height%3D%271564%27%20fill-opacity%3D%220%22%2F%3E%3C%2Fsvg%3E\" data-srcset=\"https:\/\/corlife.eu\/wp-content\/uploads\/2020\/09\/SlideshowProfessionals-Xellfree1-200x122.jpg 200w, https:\/\/corlife.eu\/wp-content\/uploads\/2020\/09\/SlideshowProfessionals-Xellfree1-400x244.jpg 400w, https:\/\/corlife.eu\/wp-content\/uploads\/2020\/09\/SlideshowProfessionals-Xellfree1-600x367.jpg 600w, https:\/\/corlife.eu\/wp-content\/uploads\/2020\/09\/SlideshowProfessionals-Xellfree1-800x489.jpg 800w, https:\/\/corlife.eu\/wp-content\/uploads\/2020\/09\/SlideshowProfessionals-Xellfree1-1200x733.jpg 1200w, https:\/\/corlife.eu\/wp-content\/uploads\/2020\/09\/SlideshowProfessionals-Xellfree1-scaled.jpg 2560w\" data-sizes=\"auto\" data-orig-sizes=\"(max-width: 700px) 100vw, 600px\" \/><\/span>\n<div class=\"fusion-clearfix\"><\/div><\/div><\/div>\n\n<div class=\"fusion-layout-column fusion_builder_column_inner fusion-builder-nested-column-4 fusion_builder_column_inner_1_2 1_2 fusion-one-half fusion-column-last\" style=\"width:48%;margin-top:0px;margin-bottom:20px;\"><div class=\"fusion-column-wrapper fusion-flex-column-wrapper-legacy\" style=\"background-position:left top;background-repeat:no-repeat;-webkit-background-size:cover;-moz-background-size:cover;-o-background-size:cover;background-size:cover;padding: 0px 0px 0px 0px;\"><div class=\"fusion-text fusion-text-3\"><h4>Die Gewebespende<\/h4>\n<p>Corlife arbeitet mit anerkannten Gewebe- und Entnahmeeinrichtungen zusammen, die geeignete Gewebespenden sorgf\u00e4ltig ausw\u00e4hlen. Die Kriterien sind in der Europ\u00e4ischen Verordnung 2024\/1938 beschrieben. Die Auswahl umfasst eine ausf\u00fchrliche Anamnese der Spenderin oder des Spenders, serologische Untersuchungen, eine \u00e4u\u00dfere und innere K\u00f6rperschau, sowie morphologische und mikrobiologische Untersuchungen der Gewebespende.<\/p>\n<\/div>\n<div class=\"fusion-clearfix\"><\/div><\/div><\/div>\n<\/div>\n\n    <\/div>\n\n\n<!-- Slide -->\n\n\n    <div id=\"slide-2\" class=\"smallslidesItem\">\n\n<div class=\"fusion-builder-row fusion-builder-row-inner fusion-row\">\n<div class=\"fusion-layout-column fusion_builder_column_inner fusion-builder-nested-column-5 fusion_builder_column_inner_1_2 1_2 fusion-one-half fusion-column-first\" style=\"width:48%; margin-right: 4%;margin-top:35px;margin-bottom:20px;\"><div class=\"fusion-column-wrapper fusion-flex-column-wrapper-legacy\" style=\"background-position:left top;background-repeat:no-repeat;-webkit-background-size:cover;-moz-background-size:cover;-o-background-size:cover;background-size:cover;padding: 0px 0px 0px 0px;\">\n<span class=\" fusion-imageframe imageframe-none imageframe-3 hover-type-none\"><img decoding=\"async\" width=\"2560\" height=\"1564\" title=\"SlideshowProfessionals Xellfree2\" src=\"https:\/\/corlife.eu\/wp-content\/uploads\/2020\/09\/SlideshowProfessionals-Xellfree2-scaled.jpg\" data-orig-src=\"\/wp-content\/uploads\/2020\/09\/SlideshowProfessionals-Xellfree2-scaled.jpg\n\" alt class=\"lazyload img-responsive wp-image-1537\" srcset=\"data:image\/svg+xml,%3Csvg%20xmlns%3D%27http%3A%2F%2Fwww.w3.org%2F2000%2Fsvg%27%20width%3D%272560%27%20height%3D%271564%27%20viewBox%3D%270%200%202560%201564%27%3E%3Crect%20width%3D%272560%27%20height%3D%271564%27%20fill-opacity%3D%220%22%2F%3E%3C%2Fsvg%3E\" data-srcset=\"https:\/\/corlife.eu\/wp-content\/uploads\/2020\/09\/SlideshowProfessionals-Xellfree2-200x122.jpg 200w, https:\/\/corlife.eu\/wp-content\/uploads\/2020\/09\/SlideshowProfessionals-Xellfree2-400x244.jpg 400w, https:\/\/corlife.eu\/wp-content\/uploads\/2020\/09\/SlideshowProfessionals-Xellfree2-600x367.jpg 600w, https:\/\/corlife.eu\/wp-content\/uploads\/2020\/09\/SlideshowProfessionals-Xellfree2-800x489.jpg 800w, https:\/\/corlife.eu\/wp-content\/uploads\/2020\/09\/SlideshowProfessionals-Xellfree2-1200x733.jpg 1200w, https:\/\/corlife.eu\/wp-content\/uploads\/2020\/09\/SlideshowProfessionals-Xellfree2-scaled.jpg 2560w\" data-sizes=\"auto\" data-orig-sizes=\"(max-width: 700px) 100vw, 600px\" \/><\/span>\n<div class=\"fusion-clearfix\"><\/div><\/div><\/div>\n\n<div class=\"fusion-layout-column fusion_builder_column_inner fusion-builder-nested-column-6 fusion_builder_column_inner_1_2 1_2 fusion-one-half fusion-column-last\" style=\"width:48%;margin-top:0px;margin-bottom:20px;\"><div class=\"fusion-column-wrapper fusion-flex-column-wrapper-legacy\" style=\"background-position:left top;background-repeat:no-repeat;-webkit-background-size:cover;-moz-background-size:cover;-o-background-size:cover;background-size:cover;padding: 0px 0px 0px 0px;\">\n<div class=\"fusion-text fusion-text-4\"><h4>Bearbeitung<\/h4>\n<p>Die Allografts werden in der h\u00f6chsten Reinraumklasse (Klasse A) bearbeitet. Sorgfalt der Mitarbeiterinnen und Mitarbeiter und sehr hohe hygienische und technische Standards verhindern eine Kontamination w\u00e4hrend der Bearbeitung. Wir beproben regelm\u00e4\u00dfig die Kontaktfl\u00e4chen um mikrobielle Kontaminationen fr\u00fchzeitig zu erkennen und ggfs. geeignete Ma\u00dfnahme zu ergreifen.<\/p>\n<\/div>\n<div class=\"fusion-clearfix\"><\/div><\/div><\/div>\n<\/div>\n    <\/div>\n\n<!-- Slide -->\n\n\n    <div id=\"slide-3\" class=\"smallslidesItem\">\n\n<div class=\"fusion-builder-row fusion-builder-row-inner fusion-row\">\n<div class=\"fusion-layout-column fusion_builder_column_inner fusion-builder-nested-column-7 fusion_builder_column_inner_1_2 1_2 fusion-one-half fusion-column-first\" style=\"width:48%; margin-right: 4%;margin-top:35px;margin-bottom:20px;\"><div class=\"fusion-column-wrapper fusion-flex-column-wrapper-legacy\" style=\"background-position:left top;background-repeat:no-repeat;-webkit-background-size:cover;-moz-background-size:cover;-o-background-size:cover;background-size:cover;padding: 0px 0px 0px 0px;\">\n<span class=\" fusion-imageframe imageframe-none imageframe-4 hover-type-none\"><a href=\"\/wp-content\/uploads\/2020\/11\/SlideshowProfessionalsXellfree3EN.jpg\n\" class=\"fusion-lightbox\" data-rel=\"iLightbox[2fbff79a153e3a9937f]\" data-title=\"SlideshowProfessionals Xellfree3\" title=\"SlideshowProfessionals Xellfree3\"><img decoding=\"async\" width=\"1200\" height=\"1167\" src=\"data:image\/svg+xml,%3Csvg%20xmlns%3D%27http%3A%2F%2Fwww.w3.org%2F2000%2Fsvg%27%20width%3D%271200%27%20height%3D%271167%27%20viewBox%3D%270%200%201200%201167%27%3E%3Crect%20width%3D%271200%27%20height%3D%271167%27%20fill-opacity%3D%220%22%2F%3E%3C%2Fsvg%3E\" data-orig-src=\"\/wp-content\/uploads\/2020\/11\/SlideshowProfessionalsXellfree3EN.jpg\n\" alt class=\"lazyload img-responsive wp-image-1538\"\/><\/a><\/span>\n<div class=\"fusion-clearfix\"><\/div><\/div><\/div>\n\n<div class=\"fusion-layout-column fusion_builder_column_inner fusion-builder-nested-column-8 fusion_builder_column_inner_1_2 1_2 fusion-one-half fusion-column-last\" style=\"width:48%;margin-top:0px;margin-bottom:20px;\"><div class=\"fusion-column-wrapper fusion-flex-column-wrapper-legacy\" style=\"background-position:left top;background-repeat:no-repeat;-webkit-background-size:cover;-moz-background-size:cover;-o-background-size:cover;background-size:cover;padding: 0px 0px 0px 0px;\">\n<div class=\"fusion-text fusion-text-5\"><h4>Zellfrei<\/h4>\n<p>Bevor wir ein zellfreies Allograft abgeben, werden Gewebeproben von einer unabh\u00e4ngigen Pathologin \/ einem unabh\u00e4ngigen Pathologen histologisch untersucht. In der bearbeiteten Gewebeprobe d\u00fcrfen keine intakten Zellkerne nachweisbar sein.<\/p>\n<\/div>\n<div class=\"fusion-clearfix\"><\/div><\/div><\/div>\n<\/div>\n\n    <\/div>\n\n\n<!-- Slide -->\n\n    <div id=\"slide-4\" class=\"smallslidesItem\">\n<div class=\"fusion-builder-row fusion-builder-row-inner fusion-row\">\n<div class=\"fusion-layout-column fusion_builder_column_inner fusion-builder-nested-column-9 fusion_builder_column_inner_1_2 1_2 fusion-one-half fusion-column-first\" style=\"width:48%; margin-right: 4%;margin-top:35px;margin-bottom:20px;\"><div class=\"fusion-column-wrapper fusion-flex-column-wrapper-legacy\" style=\"background-position:left top;background-repeat:no-repeat;-webkit-background-size:cover;-moz-background-size:cover;-o-background-size:cover;background-size:cover;padding: 0px 0px 0px 0px;\"><span class=\" fusion-imageframe imageframe-none imageframe-5 hover-type-none\"><a href=\"\/wp-content\/uploads\/2025\/01\/Xellfree-data-visualization-dsDNA.jpg\n\" class=\"fusion-lightbox\" data-rel=\"iLightbox[2d5ff6fee6c055a6556]\" data-title=\"SlideshowProfessionals Xellfree4\" title=\"SlideshowProfessionals Xellfree4\"><img decoding=\"async\" width=\"1240\" height=\"738\" src=\"data:image\/svg+xml,%3Csvg%20xmlns%3D%27http%3A%2F%2Fwww.w3.org%2F2000%2Fsvg%27%20width%3D%271240%27%20height%3D%27738%27%20viewBox%3D%270%200%201240%20738%27%3E%3Crect%20width%3D%271240%27%20height%3D%27738%27%20fill-opacity%3D%220%22%2F%3E%3C%2Fsvg%3E\" data-orig-src=\"\/wp-content\/uploads\/2025\/01\/Xellfree-data-visualization-dsDNA.jpg\n\" alt class=\"lazyload img-responsive wp-image-1539\"\/><\/a><\/span>\n<div class=\"fusion-clearfix\"><\/div><\/div><\/div>\n\n<div class=\"fusion-layout-column fusion_builder_column_inner fusion-builder-nested-column-10 fusion_builder_column_inner_1_2 1_2 fusion-one-half fusion-column-last\" style=\"width:48%;margin-top:0px;margin-bottom:20px;\"><div class=\"fusion-column-wrapper fusion-flex-column-wrapper-legacy\" style=\"background-position:left top;background-repeat:no-repeat;-webkit-background-size:cover;-moz-background-size:cover;-o-background-size:cover;background-size:cover;padding: 0px 0px 0px 0px;\"><div class=\"fusion-text fusion-text-6\"><h4>Zellfrei<\/h4>\n<p>Doppelstrang-DNA (dsDNA) ist Bestandteil der Zellkerne und somit ein Surrogatparameter f\u00fcr die Zelldichte im Gewebe. Die dsDNA-Masse in der Arterienwand ist von Gewebespende zu Gewebespende sehr unterschiedlich (150-4.250 ng\/mg, n=40). In der Literatur wird \u201czellfrei\u201d als \u226450 ng dsDNA pro mg Gewebe definiert (Crapo et al., Biomaterials. 2011 Apr; 32(12):3233-43). Die Xellfree<sup>\u00ae<\/sup>-Technologie ist anspruchsvoller: Nach Bearbeitung d\u00fcrfen nur \u226425 ng dsDNA pro mg Gewebe nachweisbar sein. Der Restgehalt betr\u00e4gt in >90% aller zellfreien Allografts (n=641) sogar nur \u226410 ng\/mg.<\/p>\n<\/div>\n<div class=\"fusion-clearfix\"><\/div><\/div><\/div>\n<\/div>\n\n    <\/div>\n\n<!-- Slide -->\n\n <div id=\"slide-5\" class=\"smallslidesItem\">\n\n<div class=\"fusion-builder-row fusion-builder-row-inner fusion-row\">\n<div class=\"fusion-layout-column fusion_builder_column_inner fusion-builder-nested-column-11 fusion_builder_column_inner_1_2 1_2 fusion-one-half fusion-column-first\" style=\"width:48%; margin-right: 4%;margin-top:35px;margin-bottom:20px;\"><div class=\"fusion-column-wrapper fusion-flex-column-wrapper-legacy\" style=\"background-position:left top;background-repeat:no-repeat;-webkit-background-size:cover;-moz-background-size:cover;-o-background-size:cover;background-size:cover;padding: 0px 0px 0px 0px;\">\n<span class=\" fusion-imageframe imageframe-none imageframe-6 hover-type-none\"><a href=\"\/wp-content\/uploads\/2020\/09\/SlideshowProfessionals-Xellfree5.jpg\n\" class=\"fusion-lightbox\" data-rel=\"iLightbox[6becf400c75958a72a4]\" data-title=\"SlideshowProfessionals Xellfree5\" title=\"SlideshowProfessionals Xellfree5\"><img decoding=\"async\" width=\"560\" height=\"560\" src=\"https:\/\/corlife.eu\/wp-content\/uploads\/2020\/09\/SlideshowProfessionals-Xellfree5.jpg\" data-orig-src=\"\/wp-content\/uploads\/2020\/09\/SlideshowProfessionals-Xellfree5.jpg\n\" alt class=\"lazyload img-responsive wp-image-1540\" srcset=\"data:image\/svg+xml,%3Csvg%20xmlns%3D%27http%3A%2F%2Fwww.w3.org%2F2000%2Fsvg%27%20width%3D%27560%27%20height%3D%27560%27%20viewBox%3D%270%200%20560%20560%27%3E%3Crect%20width%3D%27560%27%20height%3D%27560%27%20fill-opacity%3D%220%22%2F%3E%3C%2Fsvg%3E\" data-srcset=\"https:\/\/corlife.eu\/wp-content\/uploads\/2020\/09\/SlideshowProfessionals-Xellfree5-200x200.jpg 200w, https:\/\/corlife.eu\/wp-content\/uploads\/2020\/09\/SlideshowProfessionals-Xellfree5-400x400.jpg 400w, https:\/\/corlife.eu\/wp-content\/uploads\/2020\/09\/SlideshowProfessionals-Xellfree5.jpg 560w\" data-sizes=\"auto\" data-orig-sizes=\"(max-width: 700px) 100vw, 560px\" \/><\/a><\/span>\n<div class=\"fusion-clearfix\"><\/div><\/div><\/div>\n\n<div class=\"fusion-layout-column fusion_builder_column_inner fusion-builder-nested-column-12 fusion_builder_column_inner_1_2 1_2 fusion-one-half fusion-column-last\" style=\"width:48%;margin-top:0px;margin-bottom:20px;\"><div class=\"fusion-column-wrapper fusion-flex-column-wrapper-legacy\" style=\"background-position:left top;background-repeat:no-repeat;-webkit-background-size:cover;-moz-background-size:cover;-o-background-size:cover;background-size:cover;padding: 0px 0px 0px 0px;\">\n<div class=\"fusion-text fusion-text-7\"><h4>Intakte extrazellul\u00e4re Matrix<\/h4>\n<p>Jedes einzelne Allograft wird von einer unabh\u00e4ngigen Pathologin \/ einem unabh\u00e4ngigen Pathologen histologisch untersucht. Die extrazellul\u00e4re Matrix muss eine Faserstruktur aufweisen, die auf eine gesunde Spenderin oder einen gesunden Spender schlie\u00dfen l\u00e4sst. Allografts mit z.B. myxoider Faserstruktur werden verworfen.<\/p>\n<\/div>\n<div class=\"fusion-clearfix\"><\/div><\/div><\/div>\n<\/div>\n    <\/div>\n\n<!-- Slide -->\n\n <div id=\"slide-6\" class=\"smallslidesItem\">\n\n<div class=\"fusion-builder-row fusion-builder-row-inner fusion-row\">\n<div class=\"fusion-layout-column fusion_builder_column_inner fusion-builder-nested-column-13 fusion_builder_column_inner_1_2 1_2 fusion-one-half fusion-column-first\" style=\"width:48%; margin-right: 4%;margin-top:35px;margin-bottom:20px;\"><div class=\"fusion-column-wrapper fusion-flex-column-wrapper-legacy\" style=\"background-position:left top;background-repeat:no-repeat;-webkit-background-size:cover;-moz-background-size:cover;-o-background-size:cover;background-size:cover;padding: 0px 0px 0px 0px;\">\n<span class=\" fusion-imageframe imageframe-none imageframe-7 hover-type-none\"><img decoding=\"async\" width=\"2560\" height=\"2130\" title=\"SlideshowProfessionals Xellfree6\" src=\"https:\/\/corlife.eu\/wp-content\/uploads\/2020\/09\/SlideshowProfessionals-Xellfree6-scaled.jpg\" data-orig-src=\"\/wp-content\/uploads\/2020\/09\/SlideshowProfessionals-Xellfree6-scaled.jpg\n\" alt class=\"lazyload img-responsive wp-image-1541\" srcset=\"data:image\/svg+xml,%3Csvg%20xmlns%3D%27http%3A%2F%2Fwww.w3.org%2F2000%2Fsvg%27%20width%3D%272560%27%20height%3D%272130%27%20viewBox%3D%270%200%202560%202130%27%3E%3Crect%20width%3D%272560%27%20height%3D%272130%27%20fill-opacity%3D%220%22%2F%3E%3C%2Fsvg%3E\" data-srcset=\"https:\/\/corlife.eu\/wp-content\/uploads\/2020\/09\/SlideshowProfessionals-Xellfree6-200x166.jpg 200w, https:\/\/corlife.eu\/wp-content\/uploads\/2020\/09\/SlideshowProfessionals-Xellfree6-400x333.jpg 400w, https:\/\/corlife.eu\/wp-content\/uploads\/2020\/09\/SlideshowProfessionals-Xellfree6-600x499.jpg 600w, https:\/\/corlife.eu\/wp-content\/uploads\/2020\/09\/SlideshowProfessionals-Xellfree6-800x666.jpg 800w, https:\/\/corlife.eu\/wp-content\/uploads\/2020\/09\/SlideshowProfessionals-Xellfree6-1200x998.jpg 1200w, https:\/\/corlife.eu\/wp-content\/uploads\/2020\/09\/SlideshowProfessionals-Xellfree6-scaled.jpg 2560w\" data-sizes=\"auto\" data-orig-sizes=\"(max-width: 700px) 100vw, 600px\" \/><\/span>\n<div class=\"fusion-clearfix\"><\/div><\/div><\/div>\n\n<div class=\"fusion-layout-column fusion_builder_column_inner fusion-builder-nested-column-14 fusion_builder_column_inner_1_2 1_2 fusion-one-half fusion-column-last\" style=\"width:48%;margin-top:0px;margin-bottom:20px;\"><div class=\"fusion-column-wrapper fusion-flex-column-wrapper-legacy\" style=\"background-position:left top;background-repeat:no-repeat;-webkit-background-size:cover;-moz-background-size:cover;-o-background-size:cover;background-size:cover;padding: 0px 0px 0px 0px;\">\n<div class=\"fusion-text fusion-text-8\"><h4>Keimfrei<\/h4>\n<p>Jedes zellfreie Allograft wird aseptisch bearbeitet. Eine terminale Sterilisation w\u00fcrde das Allograft denaturieren und das Regenerationspotential vernichten. Von jedem Allograft werden am Ende der Bearbeitung Proben genommen, zwei Wochen in N\u00e4hrmedien bei optimalen Bedingungen inkubiert und anschlie\u00dfend auf Keimfreiheit gepr\u00fcft. Wir geben nur keimfreie, zellfreie Allografts ab.<\/p>\n<p>Links: kein Befund, Rechts: Kontaminiert<\/p>\n<\/div>\n<div class=\"fusion-clearfix\"><\/div><\/div><\/div>\n<\/div>\n    <\/div>\n\n<!-- Slide -->\n\n <div id=\"slide-7\" class=\"smallslidesItem\">\n\n<div class=\"fusion-builder-row fusion-builder-row-inner fusion-row\">\n<div class=\"fusion-layout-column fusion_builder_column_inner fusion-builder-nested-column-15 fusion_builder_column_inner_1_2 1_2 fusion-one-half fusion-column-first\" style=\"width:48%; margin-right: 4%;margin-top:35px;margin-bottom:20px;\"><div class=\"fusion-column-wrapper fusion-flex-column-wrapper-legacy\" style=\"background-position:left top;background-repeat:no-repeat;-webkit-background-size:cover;-moz-background-size:cover;-o-background-size:cover;background-size:cover;padding: 0px 0px 0px 0px;\">\n<span class=\" fusion-imageframe imageframe-none imageframe-8 hover-type-none\"><img decoding=\"async\" width=\"1200\" height=\"800\" title=\"SlideshowProfessionals Xellfree7\" src=\"https:\/\/corlife.eu\/wp-content\/uploads\/2020\/09\/SlideshowProfessionals-Xellfree7.jpg\" data-orig-src=\"\/wp-content\/uploads\/2020\/09\/SlideshowProfessionals-Xellfree7.jpg\n\" alt class=\"lazyload img-responsive wp-image-1542\" srcset=\"data:image\/svg+xml,%3Csvg%20xmlns%3D%27http%3A%2F%2Fwww.w3.org%2F2000%2Fsvg%27%20width%3D%271200%27%20height%3D%27800%27%20viewBox%3D%270%200%201200%20800%27%3E%3Crect%20width%3D%271200%27%20height%3D%27800%27%20fill-opacity%3D%220%22%2F%3E%3C%2Fsvg%3E\" data-srcset=\"https:\/\/corlife.eu\/wp-content\/uploads\/2020\/09\/SlideshowProfessionals-Xellfree7-200x133.jpg 200w, https:\/\/corlife.eu\/wp-content\/uploads\/2020\/09\/SlideshowProfessionals-Xellfree7-400x267.jpg 400w, https:\/\/corlife.eu\/wp-content\/uploads\/2020\/09\/SlideshowProfessionals-Xellfree7-600x400.jpg 600w, https:\/\/corlife.eu\/wp-content\/uploads\/2020\/09\/SlideshowProfessionals-Xellfree7-800x533.jpg 800w, https:\/\/corlife.eu\/wp-content\/uploads\/2020\/09\/SlideshowProfessionals-Xellfree7.jpg 1200w\" data-sizes=\"auto\" data-orig-sizes=\"(max-width: 700px) 100vw, 600px\" \/><\/span>\n<div class=\"fusion-clearfix\"><\/div><\/div><\/div>\n\n<div class=\"fusion-layout-column fusion_builder_column_inner fusion-builder-nested-column-16 fusion_builder_column_inner_1_2 1_2 fusion-one-half fusion-column-last\" style=\"width:48%;margin-top:0px;margin-bottom:20px;\"><div class=\"fusion-column-wrapper fusion-flex-column-wrapper-legacy\" style=\"background-position:left top;background-repeat:no-repeat;-webkit-background-size:cover;-moz-background-size:cover;-o-background-size:cover;background-size:cover;padding: 0px 0px 0px 0px;\">\n<div class=\"fusion-text fusion-text-9\"><h4>Ohne Antibiotika<\/h4>\n<p>Konventionelle Allografts werden mit einem hoch dosierten Antibiotika-Cocktail behandelt und dann eingefroren. Das Xellfree<sup>\u00ae<\/sup>-Verfahren kommt ohne Antibiotika aus.<\/p>\n<\/div>\n<div class=\"fusion-clearfix\"><\/div><\/div><\/div>\n<\/div>\n    <\/div>\n\n<!-- Slide -->\n\n <div id=\"slide-8\" class=\"smallslidesItem\">\n\n<div class=\"fusion-builder-row fusion-builder-row-inner fusion-row\">\n<div class=\"fusion-layout-column fusion_builder_column_inner fusion-builder-nested-column-17 fusion_builder_column_inner_1_2 1_2 fusion-one-half fusion-column-first\" style=\"width:48%; margin-right: 4%;margin-top:35px;margin-bottom:20px;\"><div class=\"fusion-column-wrapper fusion-flex-column-wrapper-legacy\" style=\"background-position:left top;background-repeat:no-repeat;-webkit-background-size:cover;-moz-background-size:cover;-o-background-size:cover;background-size:cover;padding: 0px 0px 0px 0px;\">\n<span class=\" fusion-imageframe imageframe-none imageframe-9 hover-type-none\"><img decoding=\"async\" width=\"1200\" height=\"800\" title=\"SlideshowProfessionals Xellfree8\" src=\"https:\/\/corlife.eu\/wp-content\/uploads\/2020\/09\/SlideshowProfessionals-Xellfree8.jpg\" data-orig-src=\"\/wp-content\/uploads\/2020\/09\/SlideshowProfessionals-Xellfree8.jpg\n\" alt class=\"lazyload img-responsive wp-image-1543\" srcset=\"data:image\/svg+xml,%3Csvg%20xmlns%3D%27http%3A%2F%2Fwww.w3.org%2F2000%2Fsvg%27%20width%3D%271200%27%20height%3D%27800%27%20viewBox%3D%270%200%201200%20800%27%3E%3Crect%20width%3D%271200%27%20height%3D%27800%27%20fill-opacity%3D%220%22%2F%3E%3C%2Fsvg%3E\" data-srcset=\"https:\/\/corlife.eu\/wp-content\/uploads\/2020\/09\/SlideshowProfessionals-Xellfree8-200x133.jpg 200w, https:\/\/corlife.eu\/wp-content\/uploads\/2020\/09\/SlideshowProfessionals-Xellfree8-400x267.jpg 400w, https:\/\/corlife.eu\/wp-content\/uploads\/2020\/09\/SlideshowProfessionals-Xellfree8-600x400.jpg 600w, https:\/\/corlife.eu\/wp-content\/uploads\/2020\/09\/SlideshowProfessionals-Xellfree8-800x533.jpg 800w, https:\/\/corlife.eu\/wp-content\/uploads\/2020\/09\/SlideshowProfessionals-Xellfree8.jpg 1200w\" data-sizes=\"auto\" data-orig-sizes=\"(max-width: 700px) 100vw, 600px\" \/><\/span><div class=\"fusion-clearfix\"><\/div><\/div><\/div>\n\n<div class=\"fusion-layout-column fusion_builder_column_inner fusion-builder-nested-column-18 fusion_builder_column_inner_1_2 1_2 fusion-one-half fusion-column-last\" style=\"width:48%;margin-top:0px;margin-bottom:20px;\"><div class=\"fusion-column-wrapper fusion-flex-column-wrapper-legacy\" style=\"background-position:left top;background-repeat:no-repeat;-webkit-background-size:cover;-moz-background-size:cover;-o-background-size:cover;background-size:cover;padding: 0px 0px 0px 0px;\"><div class=\"fusion-text fusion-text-10\"><h4>Schonend<\/h4>\n<p>Zellfreie Allografts werden zu keinem Zeitpunkt eingefroren, sondern k\u00fchl gelagert und transportiert. Die schonende Bearbeitung und Lagerung vermeidet Gefriersch\u00e4den am zellfreien Gewebe.<\/p>\n<\/div>\n<div class=\"fusion-clearfix\"><\/div><\/div><\/div>\n<\/div>\n<\/div>\n\n\n\n<\/div>\n\n<\/div>\n<\/div>\n \n\t\t\t<\/div>\n\t\t<\/div>\n\n\t\t<div class=\"akkordeon_maw_item akkordeon_maw_closed\" id=\"clinicalexperience\" onclick=\"togglestate(this)\">\n\t\t\t<div class=\"title\">\n<h5>Klinische Erfahrungen<\/h5>\n\t\t\t<\/div><br>\n\t\t\t<div class=\"content\">\n\n<!-- Nest -->\n\n\n  \n<div class=\"fusion-builder-row fusion-builder-row-inner fusion-row\">\n<div class=\"fusion-layout-column fusion_builder_column_inner fusion-builder-nested-column-19 fusion_builder_column_inner_1_1 1_1 fusion-one-full fusion-column-first fusion-column-last\" style=\"width:100%;margin-top:0px;margin-bottom:20px;\"><div class=\"fusion-column-wrapper fusion-flex-column-wrapper-legacy\" style=\"background-position:left top;background-repeat:no-repeat;-webkit-background-size:cover;-moz-background-size:cover;-o-background-size:cover;background-size:cover;padding: 0px 0px 0px 0px;\">\n<div class=\"fusion-text fusion-text-11\"><p>Zellfreie humane Herzklappen werden zur Verankerung stets mit einem mehr oder weniger langen St\u00fcck des anschlie\u00dfenden Gef\u00e4\u00dfes (Aorta ascendens, Truncus pulmonalis), das den umgebenden Klappenring tr\u00e4gt, implantiert. Die anschlie\u00dfende Gef\u00e4\u00dfprothese kann mehrere Zentimeter lang sein.<\/p>\n<h4>Keine zellul\u00e4re Immunogenit\u00e4t<\/h4>\n<p>Neumann et al. (2014) untersuchten \u00fcber drei Jahre das periphere Blut von 47 Patientinnen und Patienten, die zellfreie Pulmonalklappen erhalten haben. Es konnten keine erh\u00f6hten Spiegel an T-Zellen (CD3+, CD8+), B-Zellen (CD19+), Killer-Zellen (CD16+\/CD56+) oder T-Helferzellen (CD4+) nachgewiesen werden. Die zellfreien Pulmonalklappen waren immunologisch stumm.\n<br>\n<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3938920\/pdf\/ten.tea.2013.0316.pdf\">\u201cEarly Systemic Cellular Immune Response in Children and Young Adults Receiving Decellularized Fresh Allografts for Pulmonary Valve Replacement\u201d<\/a><\/p>\n<h4>Zellul\u00e4re Regeneration<\/h4>\n<p>Sarikouch et al. (2019) untersuchten die postoperative Einwanderung von Zellen in dezellularisierte Allotransplantate. Der relative histologische Score (100% entsprechen einer vollst\u00e4ndigen zellul\u00e4ren Restauration) in Proben, die keine Endokarditis aufwiesen (n=6), betrug 76\u00b14%. In den mesenchymalen Empf\u00e4ngerzellen wurde intrazellul\u00e4res Prokollagen Typ 1 gefunden. In Endokarditis-Proben (n=5) war der histologische Score mit 48\u00b17% signifikant niedriger, einhergehend mit Leukozyteninfiltration und Matrixabbau. Eine zellfreie Pulmonalklappe zeigte ein immunsystembedingtes Transplantatversagen. Allotransplantate, die in den ersten 12 Monaten post-OP beprobt wurden, zeigten eine d\u00fcnne Besiedlung der Media. Hinsichtlich des Restaurationsgrades wurde kein Unterschied zwischen einer zellfreien aortalen oder pulmonalen Herzklappe gefunden.\n<br><a href=\"https:\/\/www.annalsthoracicsurgery.org\/action\/showPdf?pii=S0003-4975%2819%2930414-X\">\u201cEarly Insight Into In Vivo Recellularization of Cell-Free Allogenic Heart Valves\u201d<\/a><\/p>\n<h4>Zellfreie Pulmonalklappe<\/h4>\n<p>Bis 2014 waren jahrzehntelang Rinderhalsvenen (Bovine Jugularvene, BJV) und konventionelle, kryokonservierte Allografts (kryokonserviert) die verbreitetsten Optionen f\u00fcr den Pulmonalklappenersatz bei angeborenen Herzfehlern. Seit 2014 haben sich zellfreie, humane Pulmonalklappen, Espoir PV als Alternative etabliert. Bobylev et al. verglichen 2024 den klinischen Verlauf von 319 \u201epropensity-matched\u201c Patientinnen und Patienten (Alter, Herzfehlertyp, Anzahl der vorherigen Eingriffe) nach Pulmonalklappenersatz mit einer BJV oder mit einer Espoir PV. Die Espoir-Klappen zeigten deutlich bessere 10-Jahres-Ergebnisse als BJV, mit statistisch signifikant besserer Freiheit von Endokarditis (97% vs. 87%), Explantation (96% vs. 82 %) und Degeneration (65% vs. 40%).\n<br><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC10901942\/pdf\/10561_2023_Article_10082.pdf\">\u201eMatched comparison of decellularized homografts and bovine jugular vein conduits for pulmonary valve replacement in congenital heart disease\u201c<\/a><\/p>\n<p>Im Jahr 2022 verglichen Bobylev et al. den klinischen Verlauf von 319 Patientinnen und Patienten (gleiche \u201eMatch\u201c-Kriterien wie oben) nach Pulmonalklappenersatz mit einem konventionellen, kryokonservierten Allograft oder mit einer Espoir PV. Auch hier zeigte sich eine signifikant bessere Freiheit von Explantationen f\u00fcr die Espoir-Klappe im Vergleich zum kryokonservierten Allograft (96% vs. 83%) und bessere Freiheit von strukturellen Klappenver\u00e4nderungen nach 10 Jahren (Espoir 65% und kryokonserviert 47%).\n<br><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9615428\/pdf\/ezac219.pdf\">\u201e5-Year results from the prospective European multi-centre study on decellularized homografts for pulmonary valve replacement ESPOIR Trial and ESPOIR Registry data\u201c<\/a><\/p>\n<p>Die positiven klinischen Daten best\u00e4tigen die \u00dcberlegenheit der zellfreien humanen Pulmonalklappen, Espoir PV gegen\u00fcber konventionellen Optionen \u2013 auch nach mehr als 10 Jahren post-OP.<\/p>\n<h4>Zellfreie Aortenklappe<\/h4>\n<p>Bis 2015 galten die Implantation einer konventionellen Herzklappenprothese (Bioprothese oder mechanische Prothese) sowie die Ross-Operation als die g\u00e4ngigsten Verfahren f\u00fcr den Aortenklappenersatz. Seitdem haben sich die zellfreien humanen Aortenklappen, Arise AV, als vielversprechende Alternative etabliert. Anfang 2024 beschrieben Horke et al. den klinischen Verlauf von 358 Patienten (Medianalter 23,9 Jahre), von denen 144 im Rahmen der multizentrischen ARISE-Beobachtungsstudie (2015\u20132018) prospektiv erfasst wurden. Eine Subgruppe (n= 215, Medianalter 39,2 Jahre) wurde in einem Propensity-Matching-Verfahren (unter Ber\u00fccksichtigung von Alter, Herzfehlertyp und Anzahl vorheriger Eingriffe) mit \u00e4hnlichen Kohorten verglichen, die konventionelle Prothesen erhielten oder eine Ross-Operation durchliefen. Die Ergebnisse zeigen, dass Arise-Klappen \u00fcber einen Beobachtungszeitraum von Median 5 Jahren (max. 12 Jahre) weniger unerw\u00fcnschte Nebenwirkungen aufwiesen als die Vergleichsgruppen.\n<br><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC11009017\/pdf\/ezae121.pdf\">\u201eFive-year results from a prospective, single-arm European trial on decellularized allografts for aortic valve replacement-the ARISE Study and ARISE Registry Data\u201c<\/a><\/p>\n<p>Eine Subgruppenanalyse im Kontext des Aortenklappenersatzes ist klinisch relevant, da p\u00e4diatrische Patienten aufgrund ihres ausgepr\u00e4gteren Immunsystems ein erh\u00f6htes Risiko f\u00fcr Absto\u00dfungsreaktionen aufweisen. Horke et al. untersuchten speziell diese Subgruppe (n = 143, Medianalter 10,8 Jahre). Die fr\u00fchzeitige Mortalit\u00e4t nach Arise-Klappenimplantation war signifikant niedriger im Vergleich zur Ross-Operation (0,7 % vs. 3,7 %). Das mittelfristige \u00dcberleben lag bei 97,8 % nach f\u00fcnf Jahren und bei 96,3 % nach zehn Jahren postoperativ. Unerw\u00fcnschte Ereignisse wie Reoperationen, strukturelle Klappenver\u00e4nderungen, Endokarditis oder thromboembolische Komplikationen traten in der Arise-Kohorte nach einer mittleren Nachbeobachtungszeit von 5,3 Jahren mit einer vergleichbaren H\u00e4ufigkeit auf wie in der Ross-Kohorte. Allerdings hatten Patienten mit Arise-Klappenimplantation deutlich h\u00e4ufiger kardiale Voreingriffe (59 % vs. 32,3 %) und insbesondere h\u00e4ufiger Eingriffe an der Aortenklappe (17 % vs. 2,3 %).\n<br>\nArise-Klappen sind eine therapeutische Option f\u00fcr p\u00e4diatrische Patienten mit eingeschr\u00e4nkter linksventrikul\u00e4rer Funktion, da der Eingriff auf den Ersatz der betroffenen Klappe beschr\u00e4nkt bleibt und die M\u00f6glichkeit einer sp\u00e4teren Ross-Operation bewahrt wird. Die Wahl der geeigneten Operationsmethode erfordert letztendlich eine patientenindividuelle Beurteilung unter Ber\u00fccksichtigung anatomischer und myokardialer Parameter sowie spezifischer Risikofaktoren f\u00fcr thromboembolische Ereignisse oder Blutungskomplikationen.\n<br><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC11001491\/pdf\/ezae112.pdf\">\u201cPaediatric aortic valve replacement using decellularized allografts: a multicentre update following 143 implantations and five-year mean follow-up\u201d<\/a><\/p>\n<h4>Zweifacher Klappenersatz<\/h4>\n<p>Zellfreie humane Herzklappen eignen sich auch f\u00fcr den zweifachen Ersatz. 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