Literature Review (updated week 22/2020)

Cell-free Allografts, Reviews

  • Sarikouch S, Tudorache I, Cebotari S, Horke A, Haverich A, Hilfiker A. Aortenklappenersatz: Therapieoption für junge Patienten. Dtsch Arztebl 2015; 112(35-36).
  • Neumann A, Cebotari S, Tudorache I, Haverich A, Sarikouch S. Heart valve engineering: decellularized allograft matrices in clinical practice. Biomed Tech (Berl). 2013 Oct;58(5):453-6. Review. PMID: 23729596
  • Ciubotaru A, Cebotari S, Tudorache I, Beckmann E, Hilfiker A, Haverich A. Biological heart valves. Biomed Tech (Berl). 2013 Oct;58(5):389-97. PMID: 24101369
  • Cebotari S, Tudorache I, Schilling T, Haverich A. [Heart valve and myocardial tissue engineering]. Herz. 2010 Aug;35(5):334-41. Review. German. PMID: 20631970


Cell-free Allografts, Clinical

  • Horke A, Bobylev D, Avsar M, Meyns B, Rega F, Hazekamp M et al. Paediatric aortic valve replacement using decellularized allografts. Eur J Cardiothorac Surg 2020;
  • Horke A, Tudorache I, Laufer G, Andreas M, Pomar JL, Pereda D, Quintana E, Sitges M, Meyns B, Rega F, Hazekamp M, Hübler M, Schmiady M, Pepper J, Rosendahl U, Lichtenberg A, Akhyari P, Jashari R, Boethig D, Bobylev D, Avsar M, Cebotari S, Haverich A, Sarikouch S. Early results from a prospective, single-arm European trial on decellularized allografts for aortic valve replacement: the ARISE study and ARISE Registry data. Eur J Cardiothorac Surg. 2020 May 9. pii: ezaa100. doi: 10.1093/ejcts/ezaa100. PMID 32386409
  • Urganci E, Aschacher T, Herbst C, Andreas M, Schlein J, Sandner S, Laufer G, Zimpfer D. Implantation of a decellularized aortic homograft in a child. The Multimedia Manual of Cardio-Thoracic Surgery. March 19, 2020. DOI: 10.1510/mmcts.2020.007
  • Sarikouch S, Theodoridis K, Hilfiker A, Boethig D, Laufer G, Andreas M, Cebotari S, Tudorache I, Bobylev D, Neubert L, Teiken K, Robertus JL, Jonigk D, Beerbaum P, Haverich A, Horke A. Early Insight into In-vivo recellularization of cell-free allogenic heart valves. Ann Thorac Surg. 2019 Aug;108(2):581-589. doi: 10.1016/j.athoracsur.2019.02.058. Epub 2019Mar 28. PMID 30928547
  • Boethig D, Horke A, Hazekamp M, Meyns B, Rega F, Van Puyvelde J, Hübler M, Schmiady M, Ciubotaru A, Stellin G, Padalino M, Tsang V, Jashari R, Bobylev D, Tudorache I, Cebotari S, Haverich A, Sarikouch S. A European study on decellularized homografts for pulmonary valve replacement: initial results from the prospective ESPOIR Trial and ESPOIR Registry data†. Eur J Cardiothorac Surg. 2019 Sep 1; 56(3):503-509. doi: 10.1093/ejcts/ezz054. PMID 30879050
  • Bobylev D, Sarikouch S, Tudorache I, Cvitkovic T, Söylen B, Boethig D, Theodoridis K, Bertram H, Beerbaum P, Haverich A, Cebotari S, Horke A. Double semilunar valve replacement in complex congenital heart disease using decellularized homografts. Interact Cardiovasc Thorac Surg. 2019 Jan 1;28(1):151-157. doi: 10.1093/icvts/ivy212. PMID 30016427
  • Ozawa H, Ueno T, Taira M, Toda K, Kuratani T, Sawa Y. Application of a Fresh Decellularized Pulmonary Allograft for Pulmonary Valve Replacement in Japan. Circ J. 2018; 82:1526-1533
  • Sarikouch S, Haverich A, Pepper J, Pomar JL, Hazekamp M, Padalino M, Stellin G, Meyns B, Laufer G, Andreas M, Hübler M, Schmiady M, Ciubotaru A, Horke A, Cebotari S, Tudorache I; ARISE-Trial-Investigators. Every like is not the same. J Thorac Cardiovasc Surg. 2017 Jun;153(6):1553-1555. PMID: 28526106.
  • Söylen B, Sarikouch S, Horke A. Improved Results Using Decellularized Human Valves for Children with Congenital Heart Defects. Research & Reviews: Journal of Nursing and Health Sciences. 2016.12.21.
  • Sarikouch S, Horke A, Tudorache I, Beerbaum P, Westhoff-Bleck M, Boethig D, Repind O, Maniucd L, Ciubotaru A, Haverich A, Cebotari S. Decellularized fresh homografts for pulmonary valve replacement: a decade of clinical experience. Eur J Cardiothorac Surg 2016 Aug;50(2):281-90. doi:10.1093/ejcts/ezw050 Epub 2016 Mar 24. PMID 27013071
  • d’Udekem Y. Decellularized homografts: in fashion or really superior? Eur J Cardiothorac Surg 2016 Aug;50(2):291-92. doi:10.1093/ejcts/ezw068. Epub 2016 Mar 24. PMID 27013072
  • Tudorache I, Horke A, Cebotari S, Sarikouch S, Boethig D, Breymann T, Beerbaum P, Bertram H, Westhoff-Bleck M, Theodoridis K, Bobylev D, Cheptanaru E, Ciubotaru A, Haverich A. Decellularized aortic homografts for aortic valve and aorta ascendens replacement. Eur J Cardiothorac Surg 2016 Jul;50(1):89-97. doi:10.1093/ejcts/ezw013 Epub 2016 Feb 18. PMID 26896320
  • Ueno T, Ozawa H, Taira M, Kanaya T, Toda K, Kuratani T, Sawa Y. Pulmonary Valve Replacement With Fresh Decellularized Pulmonary Allograft for Pulmonary Regurgitation After Tetralogy of Fallot Repair – First Case Report in Japan. Circ J. 2016;80(4):1041-3. PMID 26924076
  • Horke A. Decellularization of aortic valves: only time will tell. Eur J Cardiothorac Surg. 2016 Mar;49(3):707-8. doi: 10.1093/ejcts/ezv361. Epub 2015 Oct 22. PMID 26494867
  • Bobylev D, Breymann T, Boethig D, Haverich A, Ono M. Semilunar valve replacement with decellularized homograft after Damus-Kaye-Stansel anastomosis and fontan procedure. Ann Thorac Surg. 2014 May;97(5):1792-5. doi: 10.1016/j.athoracsur.2013.07.116. PMID 24792271
  • Neumann A, Sarikouch S, Breymann T, Cebotari S, Boethig D, Horke A, Beerbaum P, Westhoff-Bleck M, Bertram H, Ono M, Tudorache I, Haverich A, Beutel G. Early systemic cellular immune response in children and young adults receiving decellularized fresh allografts for pulmonary valve replacement. Tissue Eng Part A. 2014 Mar;20(5-6):1003-11. doi: 10.1089/ten.TEA.2013.0316. Epub 2014 Jan 24. PMID 24138470
  • Cebotari S, Tudorache I, Ciubotaru A, Boethig D, Sarikouch S, Goerler A, Lichtenberg A, Cheptanaru E, Barnaciuc S, Cazacu A, Maliga O, Repin O, Maniuc L, Breymann T, Haverich A. Use of fresh decellularized allografts for pulmonary valve replacement may reduce the reoperation rate in children and young adults: early report. Circulation. 2011 Sep 13;124(11 Suppl):S115-23. doi: 10.1161/CIRCULATIONAHA.110.012161. PMID 21911800


Cell-free Allografts, Preclinical

  • Iablonskii P, Cebotari S, Ciubotaru A, Sarikouch S, Hoeffler K, Hilfiker A,Haverich A, Tudorache I. Decellularized mitral valve in a long-term sheep model. Eur J Cardiothorac Surg. 2018 Jun 1;53(6):1165-1172. PMID: 29385428.
  • Goecke T, Theodoridis K, Tudorache I, Ciubotaru A, Cebotari S, Ramm R, Höffler K, Sarikouch S, Vásquez Rivera A, Haverich A, Wolkers WF, Hilfiker A. In vivo performance of freeze-dried decellularized pulmonary heart valve allo- and xenografts orthotopically implanted into juvenile sheep. Acta Biomater. 2018 Mar 1;68:41-52. PubMed PMID: 29191508.
  • Theodoridis K, Tudorache I, Cebotari S, Calistru A, Meyer T, Sarikouch S, Bara C, Haverich A, Hilfiker A. (*) Six-Year-Old Sheep as a Clinically Relevant Large Animal Model for Aortic Valve Replacement Using Tissue-Engineered Grafts Based on Decellularized Allogenic Matrix. Tissue Eng Part C Methods. 2017 Dec;23(12):953-963. PMID: 28922978.
  • Tudorache I, Theodoridis K, Baraki H, Sarikouch S, Bara C, Meyer T, Höffler K, Hartung D, Hilfiker A, Haverich A, Cebotari S. Decellularized aortic allografts versus pulmonary autografts for aortic valve replacement in the growing sheep model: haemodynamic and morphological results at 20 months after implantation. Eur J Cardiothorac Surg. 2015 Oct 24. PMID: 26503725
  • Della Barbera M, Valente M, Basso C, Thiene G. Morphologic studies of cell endogenous repopulation in decellularized aortic and pulmonary homografts implanted in sheep. Cardiovasc Pathol. 2015 Mar-Apr;24(2):102-9. doi: 10.1016/j.carpath.2014.10.001. Epub 2014 Oct 16. Erratum in: Cardiovasc Pathol. 2015 May-Jun;24(3):198. PubMed PMID: 25541180
  • Wang S, Oldenhof H, Goecke T, Ramm R, Harder M, Haverich A, Hilfiker A, Wolkers WF. Sucrose Diffusion in Decellularized Heart Valves for Freeze-Drying. Tissue Eng Part C Methods. 2015 Sep;21(9):922-31 PMID: 25809201
  • Theodoridis K, Tudorache I, Calistru A, Cebotari S, Meyer T, Sarikouch S, Bara C, Brehm R, Haverich A, Hilfiker A. Successful matrix guided tissue regeneration of decellularized pulmonary heart valve allografts in elderly sheep. Biomaterials. 2015 Jun;52:221-8. PMID: 25818428
  • Böer U, Schridde A, Anssar M, Klingenberg M, Sarikouch S, Dellmann A, Harringer W, Haverich A, Wilhelmi M. The immune response to crosslinked tissue is reduced in decellularized xenogeneic and absent in decellularized allogeneic heart valves. Int J Artif Organs. 2015 Apr;38(4):199-209. PMID: 25907532
  • Boeer U, Buettner FF, Klingenberg M, Antonopoulos GC, Meyer H, Haverich A, Wilhelmi M. Immunogenicity of intensively decellularized equine carotid arteries is conferred by the extracellular matrix protein collagen type VI. PLoS One. 2014 Aug 26;9(8):e105964. PMID: 25157402
  • Wang S, Oldenhof H, Dai X, Haverich A, Hilfiker A, Harder M, Wolkers WF. Protein stability in stored decellularized heart valve scaffolds and diffusion kinetics of protective molecules. Biochim Biophys Acta. 2014 Feb;1844(2):430-8. PMID: 24321313
  • Tudorache I, Calistru A, Baraki H, Meyer T, Höffler K, Sarikouch S, Bara C, Görler A, Hartung D, Hilfiker A, Haverich A, Cebotari S. Orthotopic replacement of aortic heart valves with tissue-engineered grafts. Tissue Eng Part A. 2013 Aug;19(15-16):1686-94. PMID: 23488793
  • Cebotari S, Tudorache I, Jaekel T, Hilfiker A, Dorfman S, Ternes W, Haverich A, Lichtenberg A. Detergent decellularization of heart valves for tissue engineering: toxicological effects of residual detergents on human endothelial cells. Artif Organs. 2010 Mar;34(3):206-10. PMID: 20447045
  • Bär A, Dorfman SE, Fischer P, Hilfiker-Kleiner D, Cebotari S, Tudorache I, Suprunov M, Haverich A, Hilfiker A. The pro-angiogenic factor CCN1 enhances the re-endothelialization of biological vascularized matrices in vitro. Cardiovasc Res. 2010 Mar 1;85(4):806-13. PMID: 19920130
  • Baraki H, Tudorache I, Braun M, Höffler K, Görler A, Lichtenberg A, Bara C, Calistru A, Brandes G, Hewicker-Trautwein M, Hilfiker A, Haverich A, Cebotari S. Orthotopic replacement of the aortic valve with decellularized allograft in a sheep model. Biomaterials. 2009 Oct;30(31):6240-6. PMID: 19703713
  • Tudorache I, Cebotari S, Sturz G, Kirsch L, Hurschler C, Hilfiker A, Haverich A, Lichtenberg A. Tissue engineering of heart valves: biomechanical and morphological properties of decellularized heart valves. J Heart Valve Dis. 2007 Sep;16(5):567-73; discussion 574. PMID: 17944130
  • Lichtenberg A, Cebotari S, Tudorache I, Hilfiker A, Haverich A. Biological scaffolds for heart valve tissue engineering. Methods Mol Med. 2007;140:309-17. PMID: 18085216
  • Lichtenberg A, Tudorache I, Cebotari S, Ringes-Lichtenberg S, Sturz G, Hoeffler K, Hurscheler C, Brandes G, Hilfiker A, Haverich A. In vitro re-endothelialization of detergent decellularized heart valves under simulated physiological dynamic conditions. Biomaterials. 2006 Aug;27(23):4221-9. PMID: 16620956
  • Lichtenberg A, Tudorache I, Cebotari S, Suprunov M, Tudorache G, Goerler H, Park JK, Hilfiker-Kleiner D, Ringes-Lichtenberg S, Karck M, Brandes G, Hilfiker A, Haverich A. Preclinical testing of tissue-engineered heart valves re-endothelialized under simulated physiological conditions. Circulation. 2006 Jul 4;114(1 Suppl):I559-65. PMID: 16820637
  • Cebotari S, Lichtenberg A, Tudorache I, Hilfiker A, Mertsching H, Leyh R, Breymann T, Kallenbach K, Maniuc L, Batrinac A, Repin O, Maliga O, Ciubotaru A, Haverich A. Clinical application of tissue engineered human heart valves using autologous progenitor cells. Circulation. 2006 Jul 4;114(1 Suppl):I132-7. PMID: 16820562
  • Lichtenberg A, Cebotari S, Tudorache I, Sturz G, Winterhalter M, Hilfiker A, Haverich A. Flow-dependent re-endothelialization of tissue-engineered heart valves. J Heart Valve Dis. 2006 Mar;15(2):287-93; discussion 293-4. PMID: 16607913



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