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Patienten-Berichte

Nick F. erhält eine zellfreie Herzklappe
Dane Zwei zellfreie Herzklappen nach Australien
Annika Mutter mit angeborenem Herzfehler
Signe Der Alltag als Herausforderung
Pieter Aktiver Vater
Nick J. kehrt zu alter Form zurück
Meldung von Nebenwirkungen

Publikationen

Reviews

Sarikouch S, Horke A, Haverich A. Tissue Engineering von Herzklappen. Deutsche Herzstiftung. Herzblatt 01/2019

Söylen B, Sarikouch S, Horke A. Improved Results Using Decellularized Human Valves for Children with Congenital Heart Defects. Research & Reviews: Journal of Nursing and Health Sciences. 2016.12.21.

Neumann A, Cebotari S, Tudorache I, Haverich A, Sarikouch S. Heart valve engineering: decellularized allograft matrices in clinical practice. Biomed Tech (Berl). 2013 Oct;58(5):453-6. Review.

Ciubotaru A, Cebotari S, Tudorache I, Beckmann E, Hilfiker A, Haverich A. Biological heart valves. Biomed Tech (Berl). 2013 Oct;58(5):389-97.

Cebotari S, Tudorache I, Schilling T, Haverich A. Heart valve and myocardial tissue engineering. Herz. 2010 Aug;35(5):334-41. Review. German.

Zellfreie Aortenklappen

Horke A, Bobylev D, Avsar M, Meyns B, Rega F, Hazekamp M et al. Paediatric aortic valve replacement using decellularized allografts. Eur J Cardiothorac Surg 2020.

Horke A, Tudorache I, Laufer G, Andreas M, Pomar JL, Pereda D, Quintana E, Sitges M, Meyns B, Rega F, Hazekamp M, Huebler M, Schmiady M, Pepper J, Rosendahl U, Lichtenberg A, Akhyari P, Jashari R, Boethig D, Bobylev D, Avsar M, Cebotari S, Haverich A, Sarikouch S. Early results from a prospective, single-arm European trial on decellularized allografts for aortic valve replacement: the ARISE study and ARISE Registry data. Eur J Cardiothorac Surg. 2020 May 9.

Urganci E, Aschacher T, Herbst C, Andreas M, Schlein J, Sandner S, Laufer G, Zimpfer D. Implantation of a decellularized aortic homograft in a child. The Multimedia Manual of Cardio-Thoracic Surgery. March 19, 2020.

Bobylev D, Sarikouch S, Tudorache I, Cvitkovic T, Soeylen B, Boethig D, Theodoridis K, Bertram H, Beerbaum P, Haverich A, Cebotari S, Horke A. Double semilunar valve replacement in complex congenital heart disease using decellularized homografts. Interact Cardiovasc Thorac Surg. 2019 Jan 1;28(1):151-157.

Sarikouch S, Haverich A, Pepper J, Pomar JL, Hazekamp M, Padalino M, Stellin G, Meyns B, Laufer G, Andreas M, Huebler M, Schmiady M, Ciubotaru A, Horke A, Cebotari S, Tudorache I; ARISE-Trial-Investigators. Every like is not the same. J Thorac Cardiovasc Surg. 2017 Jun;153(6):1553-1555.

Tudorache I, Horke A, Cebotari S, Sarikouch S, Boethig D, Breymann T, Beerbaum P, Bertram H, Westhoff-Bleck M, Theodoridis K, Bobylev D, Cheptanaru E, Ciubotaru A, Haverich A. Decellularized aortic homografts for aortic valve and aorta ascendens replacement. Eur J Cardiothorac Surg 2016 Jul;50(1):89-97.

Horke A. Decellularization of aortic valves: only time will tell. Eur J Cardiothorac Surg. 2016 Mar;49(3):707-8.

Sarikouch S, Tudorache I, Cebotari S, Horke A, Haverich A, Hilfiker A. Aortenklappenersatz: Therapieoption für junge Patienten. Dtsch Arztebl 2015; 112(35-36)

Bobylev D, Breymann T, Boethig D, Haverich A, Ono M. Semilunar valve replacement with decellularized homograft after Damus-Kaye-Stansel anastomosis and fontan procedure. Ann Thorac Surg. 2014 May;97(5):1792-5.

Zellfreie Pulmonalklappen

Boethig D, Horke A, Hazekamp M, Meyns B, Rega F, Van Puyvelde J, Huebler M, Schmiady M, Ciubotaru A, Stellin G, Padalino M, Tsang V, Jashari R, Bobylev D, Tudorache I, Cebotari S, Haverich A, Sarikouch S. A European study on decellularized homografts for pulmonary valve replacement: initial results from the prospective ESPOIR Trial and ESPOIR Registry data. Eur J Cardiothorac Surg. 2019 Sep 1; 56(3):503-509.

Bobylev D, Sarikouch S, Tudorache I, Cvitkovic T, Soeylen B, Boethig D, Theodoridis K, Bertram H, Beerbaum P, Haverich A, Cebotari S, Horke A. Double semilunar valve replacement in complex congenital heart disease using decellularized homografts. Interact Cardiovasc Thorac Surg. 2019 Jan 1;28(1):151-157.

Ozawa H, Ueno T, Taira M, Toda K, Kuratani T, Sawa Y. Application of a Fresh Decellularized Pulmonary Allograft for Pulmonary Valve Replacement in Japan. Circ J. 2018; 82:1526-1533

Sarikouch S, Horke A, Tudorache I, Beerbaum P, Westhoff-Bleck M, Boethig D, Repind O, Maniucd L, Ciubotaru A, Haverich A, Cebotari S. Decellularized fresh homografts for pulmonary valve replacement: a decade of clinical experience. Eur J Cardiothorac Surg 2016 Aug;50(2):281-90.

Ueno T, Ozawa H, Taira M, Kanaya T, Toda K, Kuratani T, Sawa Y. Pulmonary Valve Replacement With Fresh Decellularized Pulmonary Allograft for Pulmonary Regurgitation After Tetralogy of Fallot Repair – First Case Report in Japan. Circ J. 2016;80(4):1041-3.

Cebotari S, Tudorache I, Ciubotaru A, Boethig D, Sarikouch S, Goerler A, Lichtenberg A, Cheptanaru E, Barnaciuc S, Cazacu A, Maliga O, Repin O, Maniuc L, Breymann T, Haverich A. Use of fresh decellularized allografts for pulmonary valve replacement may reduce the reoperation rate in children and young adults: early report. Circulation. 2011 Sep 13;124(11 Suppl):S115-23.

Sicherheit und Regeneration

Coti I, Wenda S, Andreeva A, Kocher A, Laufer G, Fischer G, Andreas M. Donor-specific HLA antibodies after fresh decellularized vs cryopreserved native allograft implantation. HLA. 2020 Nov; 96(5):580-588.

Ebken J, Mester N, Smart I, Ramm R, Goecke T, Jashari R, Boethig D, Horke A, Cebotarib S, Tudorache I, Avsar M, Bobylev D, Haverich A, Sarikouch S, Hilfiker R. Residual immune response towards decellularized homografts may be highly individual. Eur J Cardiothorac Surg 2020; doi:10.1093/ejcts/ezaa393.

Sarikouch S, Theodoridis K, Hilfiker A, Boethig D, Laufer G, Andreas M, Cebotari S, Tudorache I, Bobylev D, Neubert L, Teiken K, Robertus JL, Jonigk D, Beerbaum P, Haverich A, Horke A. Early Insight into In-vivo recellularization of cell-free allogenic heart valves. Ann Thorac Surg. 2019 Aug;108(2):581-589.

Neumann A, Sarikouch S, Breymann T, Cebotari S, Boethig D, Horke A, Beerbaum P, Westhoff-Bleck M, Bertram H, Ono M, Tudorache I, Haverich A, Beutel G. Early systemic cellular immune response in children and young adults receiving decellularized fresh allografts for pulmonary valve replacement. Tissue Eng Part A. 2014 Mar;20(5-6):1003-11.

Präklinik

Wang S, Oldenhof H, Goecke T, Ramm R, Harder M, Haverich A, Hilfiker A, Wolkers WF. Sucrose Diffusion in Decellularized Heart Valves for Freeze-Drying. Tissue Eng Part C Methods. 2015 Sep;21(9):922-31

Boeer U, Schridde A, Anssar M, Klingenberg M, Sarikouch S, Dellmann A, Harringer W, Haverich A, Wilhelmi M. The immune response to crosslinked tissue is reduced in decellularized xenogeneic and absent in decellularized allogeneic heart valves. Int J Artif Organs. 2015 Apr;38(4):199-209.

Wang S, Oldenhof H, Dai X, Haverich A, Hilfiker A, Harder M, Wolkers WF. Protein stability in stored decellularized heart valve scaffolds and diffusion kinetics of protective molecules. Biochim Biophys Acta. 2014 Feb;1844(2):430-8.

Titterington B, Puschmann C, Shellock FG. A new vascular coupling device: assessment of MRI issues at 3-tesla. Magn Reson Imaging. 2014 Jun;32(5):585-9.

Andere

Harder M. (2020) Herausforderungen innovativer Gewebemedizin aus unternehmerischer Sicht. In: Gerke S., Taupitz J., Wiesemann C., Kopetzki C., Zimmermann H. (eds) Die klinische Anwendung von humanen induzierten pluripotenten Stammzellen. Veröffentlichungen des Instituts für Deutsches, Europäisches und Internationales Medizinrecht, Gesundheitsrecht und Bioethik der Universitäten Heidelberg und Mannheim, vol 48. Springer, Berlin, Heidelberg

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